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Restraints Impact Analysis * High Production Costs and Scalability Challenges SPPS generates roughly 13,000 kg of waste per kilogram of peptide, compared with 168-308 kg for small-molecule APIs, inflating solvent disposal bills and environmental footprints

Many of the 55,000 personnel would have to continue working, while risking not being paid during a shutdown

AACR 29:27, 1988

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cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination